The VIB Agro-Incubator: where innovative projects grow into climate-resilient solutions for agriculture

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The VIB Agro-Incubator: where innovative projects grow into climate-resilient solutions for agriculture

In a world facing climate change, one of the main challenges is to secure food production for our growing population. Agriculture will have to adapt to extended periods of drought, flooding, and mitigate pests and diseases. The high-tech VIB Agro-Incubator aims to accelerate and support the development of climate-resilient crops by facilitating public and private partnerships.

A trip through the countryside of Nevele, near Ghent, takes us to the former CropDesign (BASF) high-tech greenhouse site. The site is being revived into the VIB Agro-Incubator in collaboration with ILVO, the Flanders Institute for Agricultural, Fisheries, and Food Research. Both institutes team up to upgrade and expand the technical greenhouse installations and to run the facility. The ambition of the VIB Agro-Incubator is to set up partnerships in the agro sector and expand the existing agribiotech ecosystem by supporting entrepreneurs with innovative ideas. The Agro-Incubator provides access to their high-tech greenhouse equipment and creates, together with the expertise of VIB and ILVO, an attractive support package for established and starting agribiotech companies. Especially young entrepreneurs will benefit from the Agro-Incubator’s mentorship, enabling them to grow in the field. With the partnerships, the VIB Agro-Incubator will be the center for pioneering crop development focusing on sustainable agriculture.

The innovators

Function
Senior Scientific Advisor International Plant Biotechnology Outreach (VIB-UGent) and Scientific Advisor VIB
Function
Science Director at the VIB-UGent Center for Plant Systems Biology
Name
Dr. Johan Cardoen
Function
Biotech Board Executive and Senior Strategic Advisor at VIB
Name
Dr. Stijn Dhondt
Function
Head of the VIB Agro-Incubator
Crown gall

It started with a plant tumor

Professor Marc Van Montagu is world-famous as the founding father of plant biotechnology. In the early nineteen eighties, together with his colleague and pioneer in genetics prof. Jeff Schell, he unraveled the origin of crown galls - plant tumors caused by Agrobacteria. They discovered that the Agrobacteria inducing the crown galls possess a small piece of extra DNA, also known as the Ti-plasmid, that enables the transfer and incorporation of bacterial genes into the plant DNA. Through small adjustments to this naturally occurring process, they found a way to insert a gene of interest into the plant’s genetic material. As such, genetic transformation of plants was born.

In 1982, Van Montagu launched Plant Genetic Systems (PGS), the first agribiotech company in Europe. PGS was acquired in 1996 and its legacy today is still part of Bayer Cropscience and BASF AgSolutions. Later in 1998, he co-founded CropDesign together with prof. Dirk Inzé, as one of the pioneering plant phenotyping companies. CropDesign developed greenhouses equipped with the latest digital technologies to enable the capturing and monitoring of yield and growth-related parameters in rice under field-like conditions.

From genes to high yielding crops

Big agribiotech players from around the globe soon got interested in CropDesign’s infrastructure and know-how. The ability to transform crops with a specific gene of interest and subsequently monitor growth under various stress conditions constituted the basis for many collaborations, among others with DuPont. In 2004, Dr. Johan Cardoen became CEO further developing the company strategy which led to the acquisition of CropDesign by BASF Plant Science in 2006 and a major collaboration with Monsanto. From then, the company gradually expanded its repertoire of phenotyping capabilities in key crops such as maize, wheat, soy, cotton, and canola.

In 2016, BASF restructured its agricultural biotechnology portfolio. Projects on rice yield were discontinued while other projects in maize and soy progressed beyond the gene discovery phase. Although this led to the closure of the BASF Research & Development department based in Ghent, they maintained the phenotyping infrastructure, team, and capability. When BASF finalized the acquisition of several businesses and assets from Bayer Crop Science in 2018; the facility in Nevele became redundant. This created a potential opportunity for the existing agribiotech ecosystem in Flanders to extend their activities in automated phenotyping.

The phenotyping platform of the VIB Agro-Incubator is equipped with cameras to automatically capture the various growth parameters of the plant

A green biotech hub in Ghent

VIB is a prime source of scientific expertise, technology, and business innovation which led to the origin of many successful new agribiotech companies. VIB’s first spin-off, Devgen, started with an RNA interference (RNAi) screening platform to combat nematode infections and turned into a seed company that uses RNAi for agricultural applications. In 2012, Syngenta acquired Devgen and maintained its research & development activities in the Syngenta Ghent Innovation Center. Biotalys – formerly called AgroSavfe – develops biological pest control products based on the Nanobody® technology, and is currently commercializing its first product Evoca™ (discover the Biotalys origin story). More recent start-ups Aphea.bio and Protealis harness the power of bacteria to improve crop growth and yield. In this way, the agribiotech region in Ghent has grown over the years into a true ecosystem, full of talent and innovation. VIB-UGent Center of Plant Systems Biology (PSB) is one of the world-leading research centers in the field of plant science, not only catalyzing new ventures but also attracting collaborations with industry., including BASF. In 2021, VIB signed an agreement with BASF to acquire the site in Nevele and upgrade the facility. The strategic location in the center of the Flemish agribiotech cluster in Ghent will lead to unique partnerships with research centers and companies. Furthermore, VIB intends to make the technology available and, provide expertise and access to the capabilities to support start-ups and entrepreneurs.

Inauguration VIB Agro-incubator

Together for climate-sustainable agriculture

The inauguration of the VIB Agro-Incubator took place in October 2021 in the presence of Flemish Minister of Innovation and Agriculture Hilde Crevits. The VIB Agro-Incubator will be instrumental to develop innovative agricultural solutions meeting climate adaptation and mitigation. Together with like-minded partners such as SESVanderHave and Inari, VIB is working today towards improving sugar beet and maize cultivation respectively. In another collaboration with the Meise Botanic Garden, the drought tolerance of 200 wild bean varieties will be evaluated. When scientists understand the molecular mechanisms underlying plant growth during extended periods of drought, these findings can be translated to feed crops such as maize or soy and overall contribute to climate-resilient solutions.

The incubator operates at the interface between academia and industry. We thrive on implementing vibrant ideas combining plant research, technological engineering, and computational developments towards a green and sustainable future.
REPLACE ME
Dr. Stijn Dhondt
Head of the VIB Agro-Incubator

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